Choline: The Underconsumed and Underappreciated Essential Nutrient.

ABSTRACT: Choline has been recognized as an essential nutrient by the Food and Nutrition Board of the National Academies of Medicine since 1998. Its metabolites have structural, metabolic, and regulatory roles within the body. Humans can endogenously produce small amounts of choline via the hepatic phosphatidylethanolamine N-methyltransferase pathway. However, the nutrient must be consumed exogenously to prevent signs of deficiency. The Adequate Intake (AI) for choline was calculated at a time when dietary intakes across the population were unknown for the nutrient. Unlike the traditional National Academy of Medicine approach of calculating an AI based on observed or experimentally determined approximations or estimates of intake by a group (or groups) of healthy individuals, calculation of t

SUBMITTER: Wallace TC 

PROVIDER: S-EPMC6259877 | biostudies-literature | 2018 Nov-Dec

REPOSITORIES: biostudies-literature