Association study of genetic variation of lncRNA MALAT1 with carcinogenesis of colorectal cancer.

ABSTRACT:

Introduction

Colorectal cancer (CRC) remains a major public health concern worldwide. However, the detailed molecular mechanisms of CRC remain poorly understood.

Methods

In the current study, we evaluated associations of four genetic variants located in the promoter and gene region of long noncoding RNAs metastasis-associated lung adenocarcinoma transcript 1 (lncRNA MALAT1) with CRC susceptibility among a Chinese population with 966 CRC cases and 988 healthy controls, using a two-stage, case-control study design (400 CRC cases and 400 controls in stage 1, and 566 CRC cases and 588 controls in stage 2).

Results

We found that the minor alleles of rs619586 (OR=0.73; 95% CI=0.60-0.88; P=0.001) and rs1194338 (OR=0.80; 95% CI=0.70-0.92; P=0.001) were significa

SUBMITTER: Zhao K 

PROVIDER: S-EPMC6260139 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature