The Sterilizing Effect of Intermittent Tedizolid for Pulmonary Tuberculosis.

ABSTRACT:

Background

Linezolid exhibits remarkable sterilizing effect in tuberculosis; however, a large proportion of patients develop serious adverse events. The congener tedizolid could have a better side-effect profile, but its sterilizing effect potential is unknown.

Methods

We performed a 42-day tedizolid exposure-effect and dose-fractionation study in the hollow fiber system model of tuberculosis for sterilizing effect, using human-like intrapulmonary pharmacokinetics. Bacterial burden was examined using time to positivity (TTP) and colony-forming units (CFUs). Exposure-effect was examined using the inhibitory sigmoid maximal kill model. The exposure mediating 80% of maximal kill (EC80) was defined as the target exposure, and the lowest dose to achieve EC80 was identified in 100

SUBMITTER: Srivastava S 

PROVIDER: S-EPMC6260152 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature