Niclosamide Induces Epiboly Delay During Early Zebrafish Embryogenesis.

ABSTRACT: Niclosamide is an antihelminthic drug used worldwide for the treatment of tapeworm infections. Recent drug repurposing screens have revealed that niclosamide exhibits diverse mechanisms of action and, as a result, demonstrates promise for a number of applications, including the treatment of cancer, bacterial infections, and Zika virus. As new applications of niclosamide will require non-oral delivery routes that may lead to exposure in utero, the objective of this study was to investigate the mechanism of niclosamide toxicity during early stages of embryonic development. Using zebrafish as a model, we found that niclosamide induced a concentration-dependent delay in epiboly progression during late-blastula and early-gastrula, an effect that was dependent on exposure during the maternal-to-

SUBMITTER: Vliet SM 

PROVIDER: S-EPMC6260164 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature