Determining the Best Immunization Strategy for Protecting African Children Against Invasive Salmonella Disease.

ABSTRACT:

Background

The World Health Organization recently prequalified a typhoid conjugate vaccine (TCV), recommending its use in persons ≥6 months to 45 years residing in typhoid fever (TF)-endemic areas. We now need to consider how TCVs can have the greatest impact in the most vulnerable populations.

Methods

The Typhoid Fever Surveillance in Africa Program (TSAP) was a blood culture-based surveillance of febrile patients from defined populations presenting at healthcare facilities in 10 African countries. TF and invasive non-typhoidal Salmonella (iNTS) disease incidences were estimated for 0-10 year-olds in one-year age increments.

Results

Salmonella Typhi and iNTS were the most frequently isolated pathogens; 135 and 94 cases were identified, respectively. Analysis from thr

SUBMITTER: Jeon HJ 

PROVIDER: S-EPMC6260167 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature