Host Adaptive Immune Status Regulates Expression of the Schistosome AMP-Activated Protein Kinase.

ABSTRACT: Schistosomes exhibit profound developmental adaptations in response to the immune status of their mammalian host, including significant attenuation of parasite growth, development and reproduction in response to deficits in host adaptive immunity. These observations led us to hypothesize that schistosomes regulate the utilization of energy resources in response to immunological conditions within the host. To test this hypothesis, we identified and characterized the Schistosoma mansoni AMP-activated protein kinase (AMPK), a heterotrimeric enzyme complex that is central to regulating energy metabolism at the cellular and organismal level in eukaryotes. We show that expression of the catalytic α subunit is developmentally regulated during the parasite life cycle, with peak expression o

SUBMITTER: Hunter KS 

PROVIDER: S-EPMC6260181 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature