Modeling Structure, Stability, and Flexibility of Double-Stranded RNAs in Salt Solutions.

ABSTRACT: Double-stranded (ds) RNAs play essential roles in many processes of cell metabolism. The knowledge of three-dimensional (3D) structure, stability, and flexibility of dsRNAs in salt solutions is important for understanding their biological functions. In this work, we further developed our previously proposed coarse-grained model to predict 3D structure, stability, and flexibility for dsRNAs in monovalent and divalent ion solutions through involving an implicit structure-based electrostatic potential. The model can make reliable predictions for 3D structures of extensive dsRNAs with/without bulge/internal loops from their sequences, and the involvement of the structure-based electrostatic potential and corresponding ion condition can improve the predictions for 3D structures of dsRNAs in ion

SUBMITTER: Jin L 

PROVIDER: S-EPMC6260225 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature