Ontology highlight
ABSTRACT:
SUBMITTER: Kato Y
PROVIDER: S-EPMC6260363 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Kato Yukinari Y Ohishi Tomokazu T Kawada Manabu M Maekawa Naoya N Konnai Satoru S Itai Shunsuke S Yamada Shinji S Kaneko Mika K MK
Biochemistry and biophysics reports 20181124
Podoplanin (PDPN) is a type I transmembrane heavily glycosylated sialoglycoprotein that is expressed in normal tissues such as pulmonary type I alveolar cells, renal podocytes, and lymphatic endothelial cells. PDPN overexpression in cancerous tissue is associated with hematogenous metastasis through interactions with the C-type lectin-like receptor 2 (CLEC-2). Previously, we have reported the development of a mouse monoclonal antibody (mAb), PMab-38 (IgG<sub>1</sub>, kappa) against dog PDPN (dPD ...[more]