Bisphenol-A exposure and gene expression in human luteinized membrana granulosa cells in vitro.

ABSTRACT:

Study question

Does bisphenol-A (BPA) affect gene expression in human membrana granulosa cells (MGC)?

Summary answer

In vitro, short exposure to supra-physiological concentrations of BPA alters human MGC gene expression.

What is known already

Exposure to BPA may interfere with reproductive endocrine signaling. In vitro studies, mostly in animal models, have shown an inverse correlation between exposure to BPA and follicular growth, meiosis, and steroid hormone production in granulosa cells.

Study design, size, duration

Primary cultures of MGC obtained from 24 patients undergoing IVF (for PGD, male factor infertility or unexplained infertility) were exposed to various concentrations of BPA (0, 0.02, 0.2, 2 or 20 µg/ml) for 48 h.

Participants/materials, settin

SUBMITTER: Mansur A 

PROVIDER: S-EPMC6260419 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature