Hyperpolarized ¹³C MRI: Path to Clinical Translation in Oncology.

ABSTRACT: This white paper discusses prospects for advancing hyperpolarization technology to better understand cancer metabolism, identify current obstacles to HP (hyperpolarized) ¹³C magnetic resonance imaging's (MRI's) widespread clinical use, and provide recommendations for overcoming them. Since the publication of the first NIH white paper on hyperpolarized ¹³C MRI in 2011, preclinical studies involving [1-¹³C]pyruvate as well a number of other ¹³C labeled metabolic substrates have demonstrated this technology's capacity to provide unique metabolic information. A dose-ranging study of HP [1-¹³C]pyruvate in patients with prostate cancer established safety and feasibility of this technique. Additional studies are ongoing in prostate, brain, br

SUBMITTER: Kurhanewicz J 

PROVIDER: S-EPMC6260457 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature