The murine vaginal microbiota and its perturbation by the human pathogen group B Streptococcus.

ABSTRACT:

Background

Composition of the vaginal microbiota has significant influence on female urogenital health and control of infectious disease. Murine models are widely utilized to characterize host-pathogen interactions within the vaginal tract, however, the composition of endogenous vaginal flora remains largely undefined with modern microbiome analyses. Here, we employ 16S rRNA amplicon sequencing to establish the native microbial composition of the vaginal tract in adult C57Bl/6 J mice. We further interrogate the impact of estrous cycle and introduction of the human vaginal pathobiont, group B Streptococcus (GBS) on community state type and stability, and conversely, the impact of the vaginal microbiota on GBS persistence.

Results

Sequencing analysis revealed five distinctive

SUBMITTER: Vrbanac A 

PROVIDER: S-EPMC6260558 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature