Flavonoids modulate multidrug resistance through wnt signaling in P-glycoprotein overexpressing cell lines.

ABSTRACT:

Background

Wnt signaling has been linked with P-glycoprotein (P-gp) overexpression and which was mainly mediated by β-catenin nuclear translocation. Flavonoids have already been reported as modulators of the Wnt/β-catenin pathway and hence they may serve as promising agents in the reversal of P-gp mediated cancer multi drug resistance (MDR).

Methods

In this study, we screened selected flavonoids against Wnt/β-catenin signaling molecules. The binding interaction of flavonoids (theaflavin, quercetin, rutin, epicatechin 3 gallate and tamarixetin) with GSK 3β was determined by molecular docking. Flavonoids on P-gp expression and the components of Wnt signaling in drug-resistant KBCH^R8-5 cells were analyzed by western blotting and qRT-PCR. The MDR reversal potential of

SUBMITTER: Mohana S 

PROVIDER: S-EPMC6260573 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature