DbMPIKT: a database of kinetic and thermodynamic mutant protein interactions.

ABSTRACT:

Background

Protein-protein interactions (PPIs) play important roles in biological functions. Studies of the effects of mutants on protein interactions can provide further understanding of PPIs. Currently, many databases collect experimental mutants to assess protein interactions, but most of these databases are old and have not been updated for several years.

Results

To address this issue, we manually curated a kinetic and thermodynamic database of mutant protein interactions (dbMPIKT) that is freely accessible at our website. This database contains 5291 mutants in protein interactions collected from previous databases and the literature published within the last three years. Furthermore, some data analysis, such as mutation number, mutation type, protein pair source and net

SUBMITTER: Liu Q 

PROVIDER: S-EPMC6260753 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature