Distinct expression profiles and functions of Kindlins in breast cancer.

ABSTRACT:

Background

Kindlin-1, - 2, and - 3 are the three members of the Kindlin family. They are best known as regulators of integrin functions, contributing to fundamental biological processes such as cell survival, adhesion and migration. Their deregulation leads to diverse pathologies including a broad range of cancers in which both, tumor-promoting and tumor-inhibiting functions have been described.

Methods

To better characterize Kindlins implication in breast cancer, in vitro experiments were performed in a series of cancer cell lines. We first assessed their expression profiles and subcellular distributions. Then, their involvement in breast cancer cell morphology, migration and invasion was verified by examining phenotypic changes induced by the depletion of either isoforms u

SUBMITTER: Azorin P 

PROVIDER: S-EPMC6260766 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature