Statins and Brain Health: Alzheimer's Disease and Cerebrovascular Disease Biomarkers in Older Adults.

ABSTRACT:

Background

Statins have been proposed to reduce the risk of Alzheimer's disease (AD).

Objective

Assess whether long-term statin use was associated with neuroimaging biomarkers of aging and dementia.

Methods

Methods: We analyzed neuroimaging biomarkers in 1,160 individuals aged 65+ from the Mayo Clinic Study of Aging, a population-based prospective longitudinal study of cognitive aging.

Results

Statin-treated (5+ years of therapy) individuals had greater burden of mid-and late-life cardiovascular disease (p < 0.001) than statin-untreated (≤3 months) individuals. Lower fractional anisotropy in the genu of the corpus callosum, an early marker of cerebrovascular disease, was associated with long-term statin exposure (p < 0.035). No significant associations were ide

SUBMITTER: Ramanan VK 

PROVIDER: S-EPMC6260813 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature