Genome-scale analysis of syngas fermenting acetogenic bacteria reveals the translational regulation for its autotrophic growth.

ABSTRACT:

Background

Acetogenic bacteria constitute promising biocatalysts for the conversion of CO₂/H₂ or synthesis gas (H₂/CO/CO₂) into biofuels and value-added biochemicals. These microorganisms are naturally capable of autotrophic growth via unique acetogenesis metabolism. Despite their biosynthetic potential for commercial applications, a systemic understanding of the transcriptional and translational regulation of the acetogenesis metabolism remains unclear.

Results

By integrating genome-scale transcriptomic and translatomic data, we explored the regulatory logic of the acetogenesis to convert CO₂ into biomass and metabolites in Eubacterium limosum. The results indicate that majority of genes associated with autotrophic grow

SUBMITTER: Song Y 

PROVIDER: S-EPMC6260860 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature