Polymorphism of mitochondrial tRNA genes associated with the number of pigs born alive.

ABSTRACT:

Background

Mutations in mitochondrial tRNA genes have been widely reported association with human reproductions. It is also important to explore the effect on the number of piglets born alive (NBA). Here, 1017 sows were used to investigate the association between polymorphisms in mitochondrial tRNA genes and NBA.

Results

In total, 16 mutations were found in mitochondrial tRNA genes, of which 13 mutations were significantly associated with NBA (P < 0.05). The reproductions of mutant carriers were significantly greater than that of wild carriers by 0.989 piglets born alive/sow farrowing. To test whether the mutations altered the structure of mitochondrial tRNAs, the secondary and tertiary structures were predicted. In result, C2255T changed the secondary structure of tR

SUBMITTER: Wang D 

PROVIDER: S-EPMC6260895 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature