SIRT1 deacetylase in aging-induced neuromuscular degeneration and amyotrophic lateral sclerosis.

ABSTRACT: SIRT1 is an NAD⁺ -dependent deacetylase that functions in a variety of cells and tissues to mitigate age-associated diseases. However, it remains unknown if SIRT1 also acts to prevent pathological changes that accrue in motor neurons during aging and amyotrophic lateral sclerosis (ALS). In this study, we show that SIRT1 expression decreases in the spinal cord of wild-type mice during normal aging. Using mouse models either overexpressing or lacking SIRT1 in motor neurons, we found that SIRT1 slows age-related degeneration of motor neurons' presynaptic sites at neuromuscular junctions (NMJs). Transcriptional analysis of spinal cord shows an overlap of greater than 90% when comparing alterations during normal aging with changes during ALS, revealing a substantial upregulation in i

SUBMITTER: Herskovits AZ 

PROVIDER: S-EPMC6260920 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature