Effects of aging on liver microcirculatory function and sinusoidal phenotype.

ABSTRACT: The socioeconomic and medical improvements of the last decades have led to a relevant increase in the median age of worldwide population. Although numerous studies described the impact of aging in different organs and the systemic vasculature, relatively little is known about liver function and hepatic microcirculatory status in the elderly. In this study, we aimed at characterizing the phenotype of the aged liver in a rat model of healthy aging, particularly focusing on the microcirculatory function and the molecular status of each hepatic cell type in the sinusoid. Moreover, major findings of the study were validated in young and aged human livers. Our results demonstrate that healthy aging is associated with hepatic and sinusoidal dysfunction, with elevated hepatic vascular resistance a

SUBMITTER: Maeso-Diaz R 

PROVIDER: S-EPMC6260924 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature