Interleukin-27 as a candidate diagnostic biomarker for bacterial infection in immunocompromised pediatric patients.

ABSTRACT:

Background

Immunocompromised pediatric patients constitute a growing population that is particularly vulnerable to bacterial infection, necessitating prompt recognition and treatment. This study assessed the utility of interleukin-27 (IL-27) and procalcitonin (PCT) as biomarkers of bacterial infection among immunocompromised pediatric subjects.

Methods

This is a single-center prospective cohort study conducted from July 2016 through September 2017, drawing subjects from the inpatient units at Cincinnati Children's Hospital Medical Center (CCHMC), a large, tertiary care children's hospital. Patients were included if they fit the definition of immunocompromised and were under clinical suspicion for infection, defined by the acquisition of a blood culture at any point during th

SUBMITTER: Jacobs L 

PROVIDER: S-EPMC6261028 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature