Comprehensive computational modelling of the development of mammalian cortical connectivity underlying an architectonic type principle.

ABSTRACT: The architectonic type principle relates patterns of cortico-cortical connectivity to the relative architectonic differentiation of cortical regions. One mechanism through which the observed close relation between cortical architecture and connectivity may be established is the joint development of cortical areas and their connections in developmental time windows. Here, we describe a theoretical exploration of the possible mechanistic underpinnings of the architectonic type principle, by performing systematic computational simulations of cortical development. The main component of our in silico model was a developing two-dimensional cortical sheet, which was gradually populated by neurons that formed cortico-cortical connections. To assess different explanatory mechanisms, we varied the s

SUBMITTER: Beul SF 

PROVIDER: S-EPMC6261046 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature