Scoping Review on Use of Drugs Targeting Interleukin 1 Pathway in DIRA and DITRA.

ABSTRACT:

Introduction

Deficiencies in interleukin (IL)-1 receptor (IL-R) antagonist (DIRA) and IL-36R antagonist (DITRA) are rare genetic autoinflammatory diseases related to alterations in antagonists of the IL-1 pathway. IL-1 antagonists may represent therapeutic alternatives. Here, we aim to provide a scoping review of knowledge on use of IL-1-targeting drugs in DIRA and DITRA.

Methods

An a priori protocol was published, and the study was conducted using the methodology described in the Joanna Briggs Institute Reviewer's Manual and the recently published PRISMA Extension for Scoping Review statement. A three-step search using MEDLINE and EMBASE databases until March 2018 with additional hand searching was performed. Data charting was performed. The search, article selection, and d

SUBMITTER: Gomez-Garcia F 

PROVIDER: S-EPMC6261121 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature