Improving functional re-endothelialization of acellular liver scaffold using REDV cell-binding domain.

ABSTRACT: Engineering of functional vascularized liver tissues holds great promise in addressing donor organ shortage for transplantation. Whole organ decellularization is a cell removal method that retains the native vascular structures of the organ such that it can be anastomosed with the recipient circulation after recellularization with healthy cells. However, a main hurdle to successful implantation of bioengineered organ is the inability to efficiently re-endothelialize the vasculature with a functional endothelium, resulting in blood clotting which is the primary cause of failure in early transplant studies. Here, we present an efficient approach for enhancing re-endothelialization of decellularized rat liver scaffolds by conjugating the REDV cell-binding domain to improve attachment of endot

SUBMITTER: Devalliere J 

PROVIDER: S-EPMC6261340 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature