Acetalated Dextran Microparticles for Codelivery of STING and TLR7/8 Agonists.

ABSTRACT: Vaccines are the most effective tool for preventing infectious diseases; however, subunit vaccines, considered the safest type, suffer from poor immunogenicity and require adjuvants to create a strong and sustained immune response. As adjuvants, pathogen-associated molecular patterns (PAMPs) offer potent immunostimulatory properties and defined mechanisms of action through their cognate pattern recognition receptors (PRRs). Their activity can be further enhanced through combining two or more PAMPs, particularly those that activate multiple immune signaling pathways. However, the cytosolic localization of many PRRs requires intracellular delivery of PAMPs for optimal biological activity, which is particularly true of the stimulator of interferon genes (STING) PRR. Using acetalated dextran (

SUBMITTER: Collier MA 

PROVIDER: S-EPMC6261357 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature