Serologic Responses in Childhood Pulmonary Tuberculosis.

ABSTRACT:

Background

Identification of the Mycobacterium tuberculosis immunoproteome and antigens associated with serologic responses in adults has renewed interest in developing a serologic test for childhood tuberculosis (TB). We investigated IgG antibody responses against M. tuberculosis antigens in children with well-characterized TB.

Methods

We studied archived sera obtained from hospitalized children with suspected pulmonary TB, and classified as having confirmed TB (culture-confirmed), unlikely TB (clinical improvement without TB treatment), or unconfirmed TB (all others). A multiplexed bead-based assay for IgG antibodies against 119 M. tuberculosis antigens was developed, validated and used to test sera. The area under the curves (AUCs) of the empiric receiver-operator charact

SUBMITTER: Nonyane BAS 

PROVIDER: S-EPMC6261442 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature