Bicuspid aortic valves experience increased strain as compared to tricuspid aortic valves.

ABSTRACT:

Objective

To determine whether the leaflets of bicuspid aortic valve (BAV) experience increased strain when compared to tricuspid aortic valve (TAV) leaflets.

Background

The population at highest risk of aortic valve calcification (AVC) are individuals with BAVs. Currently, efforts to medically treat AVC are hampered by a limited understanding of the biomechanical forces involved in the molecular pathogenesis of AVC.

Methods

Surgically created BAVs and control TAVs were placed into a left heart simulator. Strains were calculated by comparing the distances between points on the aortic valve (AoV) leaflet during various time points during a simulated cardiac cycle.

Results

The fused leaflets of BAVs experience significantly more strain during systole when compare

SUBMITTER: Szeto K 

PROVIDER: S-EPMC6261454 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature