Delving deeper: Relating the behaviour of a metabolic system to the properties of its components using symbolic metabolic control analysis.

ABSTRACT: High-level behaviour of metabolic systems results from the properties of, and interactions between, numerous molecular components. Reaching a complete understanding of metabolic behaviour based on the system's components is therefore a difficult task. This problem can be tackled by constructing and subsequently analysing kinetic models of metabolic pathways since such models aim to capture all the relevant properties of the system components and their interactions. Symbolic control analysis is a framework for analysing pathway models in order to reach a mechanistic understanding of their behaviour. By providing algebraic expressions for the sensitivities of system properties, such as metabolic flux or steady-state concentrations, in terms of the properties of individual reactions it allows

SUBMITTER: Christensen CD 

PROVIDER: S-EPMC6261606 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature