Impact of an alternating first-line antibiotics strategy in febrile neutropenia.

ABSTRACT:

Background

Rising antibiotic resistance poses a challenge to the management of febrile neutropenia in patients with haematological malignancies receiving chemotherapy.

Aim

We studied an alternating first-line antibiotic strategy to determine its impact on all-cause mortality and bacteremia rates in patients with febrile neutropenia.

Methods

An alternating first-line antibiotic strategy was established in mid-2013. Data for 2012 (before strategy implementation) and 2014 (post-strategy implementation) were compared. Antibiotic Heterogeneity Index (AHI) for each of the two time-periods was also calculated.

Findings

There were 2012 admissions (26082 patient-days) in 2012 and 1843 admissions (24331 patient-days) in 2014. There was no significant difference in the ba

SUBMITTER: Tan BH 

PROVIDER: S-EPMC6261621 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature