Detecting Mild Cognitive Deficits in Parkinson's Disease: Comparison of Neuropsychological Tests.

ABSTRACT:

Background

Numerous neuropsychological tests and test versions are used in Parkinson's disease research, but their relative capacity to detect mild cognitive deficits and their comparability across studies are unknown. The objective of this study was to identify neuropsychological tests that consistently detect cognitive decline in PD across studies.

Methods

Data from 30 normed neuropsychological tests across 20 international studies in up to 2908 nondemented PD patients were analyzed. A subset of 17 tests was administered to up to 1247 healthy controls. A 2-step meta-analytic approach using standardized scores compared performance in PD with normative data.

Results

Pooled estimates of the differences between PD and site-specific healthy controls identified significan

SUBMITTER: Hoogland J 

PROVIDER: S-EPMC6261669 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature