Non-invasive quantification of tumor blood flow in prostate cancer using ¹⁵O-H₂O PET/CT.

ABSTRACT: Tumor blood flow (TBF) measurements in prostate cancer (PCa) provide an integrative index of tumor growth, which could be important for primary diagnosis and therapy response evaluation. ¹⁵O-water PET is the non-invasive gold standard but is technically demanding. The aim of this study was to compare the accuracy of three different non-invasive strategies with an invasively measured arterial input function (BSIF): Using image-derived input functions (IDIF) from either 1) a separate heart scan or 2) the pelvic scan or 3) a populations-based input function (PBIF). Nine patients with biopsy-verified PCa scheduled for prostatectomy were included. All patients were characterized with serum levels of PSA (s-PSA), multiparametric magnetic resonance imaging (mpMRI) and post-surgical his

SUBMITTER: Tolbod LP 

PROVIDER: S-EPMC6261877 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature