Abnormal asymmetries in subcortical brain volume in early adolescents with subclinical psychotic experiences.

ABSTRACT: Subcortical structures may have an important role in the pathophysiology of psychosis. Our recent mega-analysis of structural magnetic resonance imaging (MRI) data has reported subcortical volumetric and lateralization alterations in chronic schizophrenia, including leftward asymmetric increases in pallidal volume. The question remains, however, whether these characteristics may represent vulnerability to the development of psychosis or whether they are epiphenomena caused by exposure to medication or illness chronicity. Subclinical psychotic experiences (SPEs) occur in some adolescents in the general population and increase the odds of developing psychosis in young adulthood. Investigations into the association between SPEs and MRI-measured volumes of subcortical structures in the general

SUBMITTER: Okada N 

PROVIDER: S-EPMC6261944 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature