A New Role of OmpR in Acid and Osmotic Stress in Salmonella and E. coli.

ABSTRACT: Bacteria survive and respond to diverse environmental conditions and during infection inside the host by systematic regulation of stress response genes. E. coli and S. Typhimurium can undergo large changes in intracellular osmolality (up to 1.8 Osmol/kg) and can tolerate cytoplasmic acidification to at least pH_i 5.6. Recent analyses of single cells challenged a long held view that bacteria respond to extracellular acid stress by rapid acidification followed by a rapid recovery. It is now appreciated that both S. Typhimurium and E. coli maintain an acidic cytoplasm through the actions of the outer membrane protein regulator OmpR via its regulation of distinct signaling pathways. However, a comprehensive comparison of OmpR regulons between S. Typ

SUBMITTER: Chakraborty S 

PROVIDER: S-EPMC6262077 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature