Subclinical Cardiac Dysfunction Is Associated With Extracardiac Organ Damages.

ABSTRACT: Background: Several studies conducted in America or Europe have described major cardiac remodeling and diastolic dysfunction in patients with sickle cell disease (SCD). We aimed at assessing cardiac involvement in SCD in sub-Saharan Africa where SCD is the most prevalent. Methods: In Cameroon, Mali and Senegal, SCD patients and healthy controls of the CADRE study underwent transthoracic echocardiography if aged ≥10 years. The comparison of clinical and echocardiographic features between patients and controls, and the associations between echocardiographic features and the vascular complications of SCD were assessed. Results: 612 SCD patients (483 SS or Sβ⁰, 99 SC, and 19 Sβ⁺) and 149 controls were included. The prevalence of dyspnea and congestive

SUBMITTER: Menet A 

PROVIDER: S-EPMC6262341 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature