Distinct Migratory Properties of M1, M2, and Resident Macrophages Are Regulated by α_Dβ₂ and α_Mβ₂ Integrin-Mediated Adhesion.

ABSTRACT: Chronic inflammation is essential mechanism during the development of cardiovascular and metabolic diseases. The outcome of diseases depends on the balance between the migration/accumulation of pro-inflammatory (M1) and anti-inflammatory (M2) macrophages in damaged tissue. The mechanism of macrophage migration and subsequent accumulation is still not fully understood. Currently, the amoeboid adhesion-independent motility is considered essential for leukocyte migration in the three-dimensional environment. We challenge this hypothesis by studying the contribution of leukocyte adhesive receptors, integrins α_Mβ₂, and α_Dβ₂, to three-dimensional migration of M1-polarized, M2-polarized, and resident macrophages. Both integrins have a moderate expressio

SUBMITTER: Cui K 

PROVIDER: S-EPMC6262406 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature