Melody Processing Characterizes Functional Neuroanatomy in the Aging Brain.

ABSTRACT: The functional neuroanatomical mechanisms underpinning cognition in the normal older brain remain poorly defined, but have important implications for understanding the neurobiology of aging and the impact of neurodegenerative diseases. Auditory processing is an attractive model system for addressing these issues. Here, we used fMRI of melody processing to investigate auditory pattern processing in normal older individuals. We manipulated the temporal (rhythmic) structure and familiarity of melodies in a passive listening, 'sparse' fMRI protocol. A distributed cortico-subcortical network was activated by auditory stimulation compared with silence; and within this network, we identified separable signatures of anisochrony processing in bilateral posterior superior temporal lobes; melodic fam

SUBMITTER: Agustus JL 

PROVIDER: S-EPMC6262413 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature