Antiproliferative Activity and Molecular Docking of Novel Double-Modified Colchicine Derivatives.

ABSTRACT: Microtubules are tubulin polymer structures, which are indispensable for cell growth and division. Its constituent protein β-tubulin has been a common drug target for various diseases including cancer. Colchicine has been used to treat gout, but it has also been an investigational anticancer agent with a known antimitotic effect on cells. However, the use of colchicine as well as many of its derivatives in long-term treatment is hampered by their high toxicity. To create more potent anticancer agents, three novel double-modified colchicine derivatives have been obtained by structural modifications in C-4 and C-10 positions. The binding affinities of these derivatives of colchicine with respect to eight different isotypes of human β-tubulin have been calculated using docking methods. In vit

SUBMITTER: Majcher U 

PROVIDER: S-EPMC6262536 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature