Controlling the Gatekeeper: Therapeutic Targeting of Nuclear Transport.

ABSTRACT: Nuclear transport receptors of the karyopherin superfamily of proteins transport macromolecules from one compartment to the other and are critical for both cell physiology and pathophysiology. The nuclear transport machinery is tightly regulated and essential to a number of key cellular processes since the spatiotemporally expression of many proteins and the nuclear transporters themselves is crucial for cellular activities. Dysregulation of the nuclear transport machinery results in localization shifts of specific cargo proteins and associates with the pathogenesis of disease states such as cancer, inflammation, viral illness and neurodegenerative diseases. Therefore, inhibition of the nuclear transport system has future potential for therapeutic intervention and could contribute to the e

SUBMITTER: Kosyna FK 

PROVIDER: S-EPMC6262578 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature