Rituximab and Fibrillary Glomerulonephritis: Interest of B Cell Reconstitution Monitoring.

ABSTRACT: Fibrillary glomerulonephritis (FGN) is a rare glomerular disease characterized by glomerular deposition of randomly arranged non-amyloid fibrils. FGN has a poor renal prognosis and its optimal treatment is a medical challenge. Rituximab therapy has recently emerged as a promising approach even though its mechanism of action remains hypothetical. We describe the case of a 55-year-old woman with FGN successfully treated by rituximab. During the 36-month follow-up, she had three relapses of FGN, occurring each time in the context of B cell recovery. Investigation of the distribution of B cell subpopulations at the time of the third relapse showed, as previously described for some immunological diseases, an increase in the proportion of switched memory B cells relative to healthy subjects, whe

SUBMITTER: Leibler C 

PROVIDER: S-EPMC6262590 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature