Using Pupillometry to Assess the Atypical Pupillary Light Reflex and LC-NE System in ASD.

ABSTRACT: With recent advances in technology, there has been growing interest in use of eye-tracking and pupillometry to assess the visual pathway in autism spectrum disorder (ASD). Within emerging literature, an atypical pupillary light reflex (PLR) has been documented, holding potential for use as a clinical screening biomarker for ASD. This review outlines dominant theories of neuropathology associated with ASD and integrates underlying neuroscience associated with the atypical PLR through a reciprocal model of brainstem involvement and cortical underconnectivity. This review draws from animal models of ASD demonstrating disruption of cranial motor nuclei and brain imaging studies examining arousal and the influence of the locus coeruleus norepinephrine (LC-NE) system on the pupillary response. P

SUBMITTER: Lynch G 

PROVIDER: S-EPMC6262612 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature