Activation of latent transforming growth factor-β1, a conserved function for pregnancy-specific beta 1-glycoproteins.

ABSTRACT:

Study question

Do all 10 human pregnancy-specific beta 1-glycoproteins (PSGs) and murine PSG23 activate latent transforming growth factor-β1 (TGF-β1)?

Summary answer

All human PSGs and murine PSG23 activated latent TGF-β1.

What is known already

Two of the 10 members of the PSG1 family, PSG1 and PSG9, were previously shown to activate the soluble small latent complex of TGF-β1, a cytokine with potent immune suppressive functions.

Study design, size, duration

Recombinant PSGs were generated and tested for their ability to activate the small latent complex of TGF-β1 in a cell-free ELISA-based assay and in a bioassay. In addition, we tested the ability of PSG1 and PSG4 to activate latent TGF-β bound to the extracellular matrix (ECM) or on the membranes of the Jurka

SUBMITTER: Warren J 

PROVIDER: S-EPMC6262632 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature