A Controlled Impact of Optic Nerve as a New Model of Traumatic Optic Neuropathy in Mouse.

ABSTRACT:

Purpose

Traumatic optic neuropathy (TON) is the most feared visual consequence of head and ocular trauma in both military and civilian communities, for which standard treatment does not exist. Animal models are critical for the development of novel TON therapies as well as the understanding of TON pathophysiology. However, the models currently used for TON have some limitations regarding consistency and mirroring the exact pathological progression of TON in closed ocular trauma. In this study, we modified the model of controlled cortical impact and adapted it for studying TON.

Methods

We defined new standardized procedures to induce TON in mice, wherein the optic nerve is reproducibly exposed to a graded controlled impact of known velocity to produce a graded deficit in reti

SUBMITTER: Ibrahim AS 

PROVIDER: S-EPMC6262644 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature