Sex Effects on Gene Expression in Lacrimal Glands of Mouse Models of Sjogren Syndrome.

ABSTRACT:

Purpose

Sjögren syndrome is an autoimmune disease that occurs primarily in women, and is associated with lacrimal gland inflammation and aqueous-deficient dry eye. We hypothesize that sex-associated differences in lacrimal gland gene expression are very important in promoting lymphocyte accumulation in this tissue and contribute to the onset, progression, and/or severity of the inflammatory disease process. To test our hypothesis, we explored the nature and extent of sex-related differences in gene expression in autoimmune lacrimal glands.

Methods

Lacrimal glands were collected from age-matched, adult, male and female MRL/MpJ-Tnfrsf6lpr (MRL/lpr) and nonobese diabetic/LtJ (NOD) mice. Glands were processed for the analysis of differentially expressed mRNAs by using CodeLink B

SUBMITTER: Tellefsen S 

PROVIDER: S-EPMC6262646 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature