Ontology highlight
ABSTRACT:
SUBMITTER: Kirk JM
PROVIDER: S-EPMC6262761 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Nature genetics 20180917 10
The functions of most long non-coding RNAs (lncRNAs) are unknown. In contrast to proteins, lncRNAs with similar functions often lack linear sequence homology; thus, the identification of function in one lncRNA rarely informs the identification of function in others. We developed a sequence comparison method to deconstruct linear sequence relationships in lncRNAs and evaluate similarity based on the abundance of short motifs called k-mers. We found that lncRNAs of related function often had simil ...[more]