Cooperation of loss of NKX3.1 and inflammation in prostate cancer initiation.

ABSTRACT: Although it is known that inflammation plays a critical role in prostate tumorigenesis, the underlying processes are not well understood. Based on analysis of genetically engineered mouse models combined with correlative analysis of expression profiling data from human prostate tumors, we demonstrate a reciprocal relationship between inflammation and the status of the NKX3.1 homeobox gene associated with prostate cancer initiation. We find that cancer initiation in aged Nkx3.1 mutant mice correlates with enrichment of specific immune populations and increased expression of immunoregulatory genes. Furthermore, expression of these immunoregulatory genes is similarly increased in human prostate tumors having low levels of NKX3.1 expression. We further show that induction

SUBMITTER: Le Magnen C 

PROVIDER: S-EPMC6262819 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature