Preliminary insights into the genetics of bank vole tolerance to Puumala hantavirus in Sweden.

ABSTRACT: Natural reservoirs of zoonotic pathogens generally seem to be capable of tolerating infections. Tolerance and its underlying mechanisms remain difficult to assess using experiments or wildlife surveys. High-throughput sequencing technologies give the opportunity to investigate the genetic bases of tolerance, and the variability of its mechanisms in natural populations. In particular, population genomics may provide preliminary insights into the genes shaping tolerance and potentially influencing epidemiological dynamics. Here, we addressed these questions in the bank vole Myodes glareolus, the specific asymptomatic reservoir host of Puumala hantavirus (PUUV), which causes nephropathia epidemica (NE) in humans. Despite the continuous spatial distribution of M. glareolus in Swe

SUBMITTER: Rohfritsch A 

PROVIDER: S-EPMC6262921 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature