Latitudinal differences on the global epidemiology of infantile spasms: systematic review and meta-analysis.

ABSTRACT:

Background

Infantile spasms represent the catastrophic, age-specific seizure type associated with acute and long-term neurological morbidity. However, due to rarity and heterogenous determination, there is persistent uncertainty of its pathophysiological and epidemiological characteristics. The purpose of the current study was to address a historically suspected latitudinal basis of infantile spasms incidence, and to interrogate a geographical basis of epidemiology, including the roles of latitude and other environmental factors, using meta-analytic and -regression methods.

Methods

A systematic search was performed in Ovid MEDLINE and Embase for primary reports on infantile spasms incidence and prevalence epidemiology.

Results

One thousand fifteen studies were screene

SUBMITTER: Jia JL 

PROVIDER: S-EPMC6262963 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature