Neurolin expression in the optic nerve and immunoreactivity of Pax6-positive niches in the brain of rainbow trout (Oncorhynchus mykiss) after unilateral eye injury.

ABSTRACT: In contrast to astrocytes in mammals, fish astrocytes promote axon regeneration after brain injury and actively participate in the regeneration process. Neurolin, a regeneration-associated, Zn8-labeled protein, is involved in the repair of damaged optic nerve in goldfish. At 1 week after unilateral eye injury, the expression of neurolin in the optic nerve and chiasm, and the expression of Pax6 that influences nervous system development in various brain regions in the rainbow trout (Oncorhynchus mykiss) were detected. Immunohistochemical staining revealed that the number of Zn8⁺ cells in the optic nerve head and intraorbital segment was obviously increased, and the increase in Zn8⁺ cells was also observed in the proximal and distal parts of injured optic nerve. This su

SUBMITTER: Pushchina EV 

PROVIDER: S-EPMC6263006 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature