Non-small cell lung cancer clinical trials requiring biopsies with biomarker-specific results for enrollment provide unique challenges.

ABSTRACT:

Background

Clinical trials in lung cancer increasingly require patients to provide fresh tumor tissue as a prerequisite to enrollment. The effects of this requirement on enrollment rates, enrollment durations, and patient selection have not been fully elucidated.

Methods

The authors retrospectively reviewed data generated by patients who consented to 1 or more interventional lung cancer clinical trials at the University of California-Los Angeles Jonsson Comprehensive Cancer Center between January 2013 and December 2014. Trials were considered to require a biopsy when enrollment was conditional on the procurement of tissue without intervening therapy between procurement and enrollment.

Results

In total, 311 patients underwent 368 screening incidents for 1 or more of 19

SUBMITTER: Spiegel ML 

PROVIDER: S-EPMC6263029 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature