Orthogonal muscle fibres have different instructive roles in planarian regeneration.

ABSTRACT: The ability to regenerate missing body parts exists throughout the animal kingdom. Positional information is crucial for regeneration, but how it is harboured and used by differentiated tissues is poorly understood. In planarians, positional information has been identified from study of phenotypes caused by RNA interference in which the wrong tissues are regenerated. For example, inhibition of the Wnt signalling pathway leads to regeneration of heads in place of tails. Characterization of these phenotypes has led to the identification of position control genes (PCGs)-genes that are expressed in a constitutive and regional manner and are associated with patterning. Most PCGs are expressed within planarian muscle; however, how muscle is specified and how different muscle subsets affect regen

SUBMITTER: Scimone ML 

PROVIDER: S-EPMC6263039 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature