Refined Analysis of Prostate-specific Antigen Kinetics to Predict Prostate Cancer Active Surveillance Outcomes.

ABSTRACT:

Background

For men on active surveillance for prostate cancer, utility of prostate-specific antigen (PSA) kinetics (PSAk) in predicting pathologic reclassification remains controversial.

Objective

To develop prediction methods for utilizing serial PSA and evaluate frequency of collection.

Design, setting, and participants

Data were collected from men enrolled in the multicenter Canary Prostate Active Surveillance Study, for whom PSA data were measured and biopsies performed on prespecified schedules. We developed a PSAk parameter based on a linear mixed-effect model (LMEM) that accounted for serial PSA levels.

Outcome measurements and statistical analysis

The association of diagnostic PSA and/or PSAk with time to reclassification (increase in cancer grade and/o

SUBMITTER: Cooperberg MR 

PROVIDER: S-EPMC6263168 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature